Changes in Physiological Tendon Substrate Stiffness Have Moderate Effects on Tendon-Derived Cell Growth and Immune Cell Activation

Changes in Physiological Tendon Substrate Stiffness Have Moderate Effects on Tendon-Derived Cell Growth and Immune Cell Activation

Tendinopathy is characterised by pathological changes in tendon matrix composition, architecture, and stiffness, alterations in tendon resident cell characteristics, and fibrosis, with inflammation also emerging as an important factor in tendinopathy progression. The sequence of pathological changes...

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Bibliographic Details
Main Authors: Subhajit Konar, Scott M. Bolam, Brendan Coleman, Nicola Dalbeth, Sue R. McGlashan, Sophia Leung, Jillian Cornish, Dorit Naot, David S. Musson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
tendon
ECM–extracellular matrix
inflammation
stiffness
tendinopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.800748/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.800748/full

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