PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

Summary: PINK1 and Parkin are established mediators of mitophagy, the selective removal of damaged mitochondria by autophagy. PINK1 and Parkin have been proposed to act as tumor suppressors, as loss-of-function mutations are correlated with enhanced tumorigenesis. However, it is unclear how PINK1 an...

Full description

Bibliographic Details
Main Authors: Shireen A. Sarraf, Dionisia P. Sideris, Nikolaos Giagtzoglou, Lina Ni, Mark W. Kankel, Anindya Sen, Lauren E. Bochicchio, Chiu-Hui Huang, Samuel C. Nussenzweig, Stuart H. Worley, Paul D. Morton, Spyros Artavanis-Tsakonas, Richard J. Youle, Alicia M. Pickrell
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719311477

Internet

http://www.sciencedirect.com/science/article/pii/S2211124719311477

Similar Items