Large-scale assessment of pros and cons of autopsy-derived or tumor-matched tissues as the norms for gene expression analysis in cancers

Large-scale assessment of pros and cons of autopsy-derived or tumor-matched tissues as the norms for gene expression analysis in cancers

Normal tissues are essential for studying disease-specific differential gene expression. However, healthy human controls are typically available only in postmortal/autopsy settings. In cancer research, fragments of pathologically normal tissue adjacent to tumor site are frequently used as the contro...

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Main Authors: Maksim Sorokin, Anton A. Buzdin, Anastasia Guryanova, Victor Efimov, Maria V. Suntsova, Marianna A. Zolotovskaia, Elena V. Koroleva, Marina I. Sekacheva, Victor S. Tkachev, Andrew Garazha, Kristina Kremenchutckaya, Aleksey Drobyshev, Aleksander Seryakov, Alexander Gudkov, Irina V. Alekseenko, Olga Rakitina, Maria B. Kostina, Uliana Vladimirova, Aleksey Moisseev, Dmitry Bulgin, Elena Radomskaya, Viktor Shestakov, Vladimir P. Baklaushev, Vladimir Prassolov, Petr V. Shegay, Xinmin Li, Elena V. Poddubskaya, Nurshat Gaifullin
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Cancer research
Molecular pathology
Autopsy
Tumor matched pathologically normal tissues
Healthy tissue controls
Differential gene expression analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702300274X

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http://www.sciencedirect.com/science/article/pii/S200103702300274X

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