HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells

HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells

Immune-inhibitory barriers in the tumor microenvironment of solid cancers counteract effective T cell therapies. Based on our finding that Ewing sarcomas (EwS) respond to chimeric antigen receptor (CAR) gene-modified effector cells through upregulation of human leukocyte antigen G (HLA-G), we hypoth...

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Bibliographic Details
Main Authors: Bianca Altvater, Sareetha Kailayangiri, Lina F. Pérez Lanuza, Katja Urban, Lea Greune, Maike Flügge, Jutta Meltzer, Nicole Farwick, Simone König, Dennis Görlich, Wolfgang Hartmann, Claudia Rossig
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
cellular immunotherapy
checkpoint inhibitors
Ewing sarcoma
HLA-G
HLA-E
Online Access:https://www.mdpi.com/2072-6694/13/12/2857

Internet

https://www.mdpi.com/2072-6694/13/12/2857

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