CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

C3 Glomerulopathy (C3G) and Immune Complex-Mediated Membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases characterized by glomerular deposition of C3 caused by dysregulation of the alternative pathway (AP) of complement. In approximately 20% of affected patients, dysregulation is dri...

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Bibliographic Details
Main Authors: Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J. H. Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
C3 glomerulopathy (C3G)
immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN)
factor H (FH)
factor H-related proteins (FHRs)
complement
copy number variations (CNVs)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.670727/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.670727/full

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