Mathematical modeling and stochastic simulations suggest that low-affinity peptides can bisect MHC1-mediated export of high-affinity peptides into “early”- and “late”-phases

Mathematical modeling and stochastic simulations suggest that low-affinity peptides can bisect MHC1-mediated export of high-affinity peptides into “early”- and “late”-phases

The peptide loading complex (PLC) is a multi-protein complex of the endoplasmic reticulum (ER) which optimizes major histocompatibility I (MHC1)-mediated export of intracellular high-affinity peptides. Whilst, the molecular biology of MHC1-mediated export is well supported by empirical data, the sto...

Full description

Bibliographic Details
Main Author: Siddhartha Kundu
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Low-affinity peptides
Major histocompatibility complex
Peptide loading complex
PLC-assembly/disassembly
Peptide editing
Shunt reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021015693

Internet

http://www.sciencedirect.com/science/article/pii/S2405844021015693

Similar Items