Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasi...

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Bibliographic Details
Main Authors: Shuyang Traub, Daniel T. Meier, Friederike Schulze, Erez Dror, Thierry M. Nordmann, Nicole Goetz, Norina Koch, Elise Dalmas, Marc Stawiski, Valmir Makshana, Fabrizio Thorel, Pedro L. Herrera, Marianne Böni-Schnetzler, Marc Y. Donath
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
GLP-1
DPP-4
glucagon
insulin
α cell
β cell
islet
diabetes
paracrine
glucose homeostasis
sitagliptin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303224

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http://www.sciencedirect.com/science/article/pii/S2211124717303224

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