Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts

Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts

Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating sepsis mortality. Because TIGIT is significantly upreg...

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Bibliographic Details
Main Authors: Yini Sun, Jerome C. Anyalebechi, He Sun, Tetsuya Yumoto, Ming Xue, Danya Liu, Zhe Liang, Craig M. Coopersmith, Mandy L. Ford
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-03-01
Series:JCI Insight
Subjects:
Infectious disease
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.141245

Internet

https://doi.org/10.1172/jci.insight.141245

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