FAdV-4 without Fiber-2 Is a Highly Attenuated and Protective Vaccine Candidate

FAdV-4 without Fiber-2 Is a Highly Attenuated and Protective Vaccine Candidate

ABSTRACT Hepatitis-hydropericardium syndrome (HHS) caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4) has resulted in huge economic losses to the poultry industry globally. The fiber-2 gene, as a major virulence determiner, is also an important vaccine target against FAdV-4. In this...

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Bibliographic Details
Main Authors: Quan Xie, Weikang Wang, Qiuqi Kan, Yaru Mu, Wei Zhang, Jian Chen, Luyuan Li, Hui Fu, Tuofan Li, Zhimin Wan, Wei Gao, Hongxia Shao, Aijian Qin, Jianqiang Ye
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
FAdV-4
CRISPR/Cas9
deletion of fiber-2
virus rescuing
pathogenesis
protection
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01436-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.01436-21

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