Ivabradine increases the high frequency gain ratio in the vagal heart rate transfer function via an interaction with muscarinic potassium channels

Ivabradine increases the high frequency gain ratio in the vagal heart rate transfer function via an interaction with muscarinic potassium channels

Abstract Muscarinic potassium channels (IK,ACh) are thought to contribute to the high frequency (HF) dynamic heart rate (HR) response to vagal nerve stimulation (VNS) because they act faster than the pathway mediated by hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels. However, the...

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Bibliographic Details
Main Authors: Toru Kawada, Hiromi Yamamoto, Tadayoshi Miyamoto, Yohsuke Hayama, Meihua Li, Can Zheng, Kazunori Uemura, Masaru Sugimachi, Keita Saku
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Physiological Reports
Subjects:
ivabradine
transfer function
vagal nerve stimulation
white noise
Online Access:https://doi.org/10.14814/phy2.15134

Internet

https://doi.org/10.14814/phy2.15134

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