Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA

Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA

Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as protein kinase...

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Bibliographic Details
Main Authors: Jared P. Taylor, Lucas H. Armitage, Daniel L. Aldridge, Melanie N. Cash, Mark A. Wallet
Format: Article
Language:English
Published: The Company of Biologists 2020-12-01
Series:Biology Open
Subjects:
harmine
latency
hiv
Online Access:http://bio.biologists.org/content/9/12/bio052969

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