Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks

Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks

Background: Mutations in MECP2 predominantly cause Rett syndrome and can be modeled in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures. Human stem cell–derived MECP2 null excitatory neurons have smaller soma size and...

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Bibliographic Details
Main Authors: Kartik S. Pradeepan, Fraser P. McCready, Wei Wei, Milad Khaki, Wenbo Zhang, Michael W. Salter, James Ellis, Julio Martinez-Trujillo
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biological Psychiatry Global Open Science
Subjects:
Burst detection
Human stem cell-derived neurons
Multielectrode array
Rett syndrome
Reverberations
Online Access:http://www.sciencedirect.com/science/article/pii/S266717432400003X

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http://www.sciencedirect.com/science/article/pii/S266717432400003X

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