Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks
Background: Mutations in MECP2 predominantly cause Rett syndrome and can be modeled in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures. Human stem cell–derived MECP2 null excitatory neurons have smaller soma size and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
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| Series: | Biological Psychiatry Global Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266717432400003X |