Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the C. elegans zygote, germline RNA granules, called P granules,...

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Bibliographic Details
Main Authors: Jarrett Smith, Deepika Calidas, Helen Schmidt, Tu Lu, Dominique Rasoloson, Geraldine Seydoux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
RNA granules
P granules
phase separation
MEX-5
MEG-3
germline
Online Access:https://elifesciences.org/articles/21337

Internet

https://elifesciences.org/articles/21337

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