Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury

Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury

Abstract Mice with inducible urothelial deletion of fibroblast growth factor receptor 2 (ShhCreERT2;Fgfr2Fl/Fl) injured with cyclophosphamide had aberrant basal cell endoreplication and poor regeneration. The endoreplication correlated with an absence of phosphorylated (activated) ERK expression in...

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Bibliographic Details
Main Authors: Sridhar Tatarao Narla, Joanne Lindsey Duara, Daniel Scott Bushnell, Mehdi Nouraie, Jacqueline Holden, Katherine Pfister, Peter C. Lucas, Sunder Sims‐Lucas, Carlton Matthew Bates
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Physiological Reports
Subjects:
bladder
cyclophosphamide
ERK
fibroblast growth factor receptor 2
urothelium
Online Access:https://doi.org/10.14814/phy2.15378

Internet

https://doi.org/10.14814/phy2.15378

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