In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Of the hepatic cell lines developed for in vitro studies of hepatic functions as alternatives to primary human hepatocytes, many have lost major liver-like functions, but not HepaRG cells. The increasing use of the latter worldwide raises the need for establishing the reference functional status of...

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Bibliographic Details
Main Authors: Georg Tascher, Audrey Burban, Sandrine Camus, Marine Plumel, Stéphanie Chanon, Remy Le Guevel, Valery Shevchenko, Alain Van Dorsselaer, Etienne Lefai, Christiane Guguen-Guillouzo, Fabrice Bertile
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
Hepatocytes
liver cell lines
HepaRG cells
proteome
secretome
hepatic phenotype
detoxification
liver metabolism
liver diseases
transdifferentiation
Online Access:https://www.mdpi.com/2073-4409/8/2/192

Internet

https://www.mdpi.com/2073-4409/8/2/192

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