Deubiquitinase OTUD5 as a Novel Protector against 4‐HNE‐Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Deubiquitinase OTUD5 as a Novel Protector against 4‐HNE‐Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Abstract Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number of patients experience high mortality due to myocardial ischemia‐reperfusion (MI/R) injury. An in‐depth understanding of the mechanisms underlying MI/R...

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Bibliographic Details
Main Authors: Lulu Liu, Jiaojiao Pang, Dandan Qin, Ruochuan Li, Dan Zou, Kai Chi, Wenxiao Wu, Haiying Rui, Huaxiang Yu, Wenyong Zhu, Kai Liu, Xuting Wu, Jinxin Wang, Ping Xu, Xiaoshuai Song, Yihai Cao, Jiali Wang, Feng Xu, Li Xue, Yuguo Chen
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
4‐hydroxy‐2‐nonenal (4‐HNE)
ferroptosis
glutathione peroxidase 4 (GPX4)
myocardial ischemia reperfusion injury
ovarian tumor (OTU) deubiquitinase 5 (OTUD5)
Online Access:https://doi.org/10.1002/advs.202301852

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https://doi.org/10.1002/advs.202301852

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