Nitric oxide regulates adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells

Nitric oxide regulates adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells

Anoikis is a type of apoptosis that occurs in response to the loss of adhesion to the extracellular matrix (ECM). Anoikis resistance is a critical mechanism in cancer and contributes to tumor metastasis. Nitric oxide (NO) is frequently upregulated in the tumor area and is considered an important pla...

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Bibliographic Details
Main Authors: A.P.S. Mesquita, M. Matsuoka, S.A. Lopes, P.C.A. Pernambuco Filho, A.S. Cruz, H.B. Nader, C.C. Lopes
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2022-02-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Anoikis resistance
Nitric oxide
Endothelial nitric oxide synthase (eNOS)
Metalloproteinase-2 (MMP-2)
Endothelial cell
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100611&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100611&tlng=en

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