The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, but it is not well understood how these and other p...
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
Public Library of Science (PLoS)
2011-04-01
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| श्रृंखला: | PLoS Genetics |
| ऑनलाइन पहुंच: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001361&type=printable |