Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus

Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus

ABSTRACT Packaging of genomic RNA (gRNA) by retroviruses is essential for infectivity, yet the subcellular site of the initial interaction between the Gag polyprotein and gRNA remains poorly defined. Because retroviral particles are released from the plasma membrane, it was previously thought that G...

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Bibliographic Details
Main Authors: Rebecca J. Kaddis Maldonado, Breanna Rice, Eunice C. Chen, Kevin M. Tuffy, Estelle F. Chiari, Kelly M. Fahrbach, Thomas J. Hope, Leslie J. Parent
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
Gag proteins
RNA trafficking
Rous sarcoma virus
genomic RNA packaging
live cell imaging
nucleocytoplasmic trafficking
Online Access:https://journals.asm.org/doi/10.1128/mBio.00524-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00524-20

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