Low pre-existing endemic human coronavirus (HCoV-NL63)-specific T cell frequencies are associated with impaired SARS-CoV-2-specific T cell responses in people living with HIV

Low pre-existing endemic human coronavirus (HCoV-NL63)-specific T cell frequencies are associated with impaired SARS-CoV-2-specific T cell responses in people living with HIV

BackgroundUnderstanding how HIV affects SARS-CoV-2 immunity is crucial for managing COVID-19 in sub-Saharan populations due to frequent coinfections. Our previous research showed that unsuppressed HIV is associated with weaker immune responses to SARS-CoV-2, but the underlying mechanisms are unclear...

Full description

Bibliographic Details
Main Authors: Tiza L. Ng’uni, Vernon Musale, Thandeka Nkosi, Jonathan Mandolo, Memory Mvula, Clive Michelo, Farina Karim, Mohomed Yunus S. Moosa, Khadija Khan, Kondwani Charles Jambo, Willem Hanekom, Alex Sigal, William Kilembe, Zaza M. Ndhlovu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
HIV
SARS-CoV-2
HCoV-NL63
COVID-19
T-cell response
antibody response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291048/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291048/full

Similar Items