Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits.

Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits.

Prolongation of action potential duration (APD), increased spatial APD dispersion, and triangulation are major factors promoting drug-induced ventricular arrhythmia. Preclinical identification of HERG/IKr-blocking drugs and their pro-arrhythmic potential, however, remains a challenge. We hypothesize...

Full description

Bibliographic Details
Main Authors: David Ziupa, Julia Beck, Gerlind Franke, Stefanie Perez Feliz, Maximilian Hartmann, Gideon Koren, Manfred Zehender, Christoph Bode, Michael Brunner, Katja E Odening
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4170956?pdf=render

Internet

http://europepmc.org/articles/PMC4170956?pdf=render

Similar Items