Homodimerized cytoplasmic domain of PD-L1 regulates its complex glycosylation in living cells

Homodimerized cytoplasmic domain of PD-L1 regulates its complex glycosylation in living cells

Membrane-anchored PD-L1 homodimerizes in cells. N-glycosylation of PD-L1 regulates its homodimerization. The formation of PD-L1 homodimers further regulates their glycan processing, localization to the plasma membrane, and binding to PD-1.

Bibliographic Details
Main Authors: Li Zhou, Fangni Chai, Yong He, Zhihui Zhou, Shupan Guo, Pan Li, Qi Sun, Xueyin Zu, Xin Liu, Qin Huang, Yanping Zhong, Aolan Zhou, Xueyun Wang, Haiyan Ren
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03845-4

Internet

https://doi.org/10.1038/s42003-022-03845-4

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