Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

Abstract Background Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of Alzheimer’s disease (AD), but interactions among these features remain poorly understood. Our previous multiscale molecular network models of AD revealed TYROBP as a key driver of an immune- and microglia-...

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Bibliographic Details
Main Authors: Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E. Ehrlich, Philip L. De Jager, David A. Bennett, Eric E. Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M. Iijima
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
Amyloid-β (Aβ) peptides
Microtubule-associated protein tau
TYROBP (tyrosine kinase binding protein)
TREM2 (triggering receptor expressed on myeloid cells 2)
Differential expression
Online Access:http://link.springer.com/article/10.1186/s13073-018-0530-9

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http://link.springer.com/article/10.1186/s13073-018-0530-9

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