The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment

The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment

BackgroundHormones and immune imbalance are critical factors in polycystic ovary syndrome (PCOS). The alternation of immune microenvironment of oocytes may play a significant role in infertility of PCOS patients.ObjectiveThis study explores the role of follicular fluid microenvironment change in inf...

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Bibliographic Details
Main Authors: Yishan Liu, Hao Liu, Zitao Li, Hualin Fan, Xiumin Yan, Xiao Liu, Jianyan Xuan, Du Feng, Xiangcai Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
polycystic ovary syndrome (PCOS)
granulosa cells (GCs)
follicular fluid (FF)
microenvironment
NF-κB
NLRP3 inflammasomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.685724/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.685724/full

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