Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice

Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice

Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na+/H+ exchange, but apical proton uptake is undefined. We found high expression of the Cl−/H+ exchanger ClC3 at the bone apical surface. In mammals ClC3 functions in intracellular vesic...

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Bibliographic Details
Main Authors: Irina L. Tourkova, Quitterie C. Larrouture, Silvia Liu, Jianhua Luo, Katherine E. Shipman, Kelechi M. Onwuka, Ora A. Weisz, Vladimir Riazanski, Deborah J. Nelson, Matthew L. MacDonald, Paul H. Schlesinger, Harry C. Blair
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Bone Reports
Subjects:
ClC3
ClC5
Bone formation rate
Mineral transport
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187224000305

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http://www.sciencedirect.com/science/article/pii/S2352187224000305

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