Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli

Abstract The genome‐scale model (GEM) of metabolism in the bacterium Escherichia coli K‐12 has been in development for over a decade and is now in wide use. GEM‐enabled studies of E. coli have been primarily focused on six applications: (1) metabolic engineering, (2) model‐driven discovery, (3) pred...

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Bibliographic Details
Main Authors: Douglas McCloskey, Bernhard Ø Palsson, Adam M Feist
Format: Article
Language:English
Published: Springer Nature 2013-04-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2013.18