Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli

The genome‐scale model (GEM) of metabolism in the bacterium Escherichia coli K‐12 has been in development for over a decade and is now in wide use. GEM‐enabled studies of E. coli have been primarily focused on six applications: (1) metabolic engineering, (2) model‐driven discovery, (3) prediction of...

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Bibliographic Details
Main Authors: Douglas McCloskey, Bernhard Ø Palsson, Adam M Feist
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2013.18