Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

IntroductionThe apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system. As a class A GPCR, targeting the apelin receptor is an attractive therapeutic strategy. With improvements in imaging techniq...

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Bibliographic Details
Main Authors: Thomas L. Williams, Robyn G. C. Macrae, Rhoda E. Kuc, Alastair J. H. Brown, Janet J. Maguire, Anthony P. Davenport
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
GPCR
apelin receptor
apelin
elabela/toddler
fluorescent ligand
stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1139121/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1139121/full

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