Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2<sup>P497H</sup> Mutation

Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2<sup>P497H</sup> Mutation

<i>Ubiquilin-2</i> (UBQLN2) mutations lead to familial amyotrophic lateral sclerosis (FALS)/and frontotemporal dementia (FTLD) through unknown mechanisms. The combination of iPSC technology and CRISPR-mediated genome editing technology can generate an iPSC-derived motor neuron (iPSC-MN)...

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Bibliographic Details
Main Authors: Yiti Zhang, Baitao Zeng, Ao Gu, Qinyu Kang, Mingri Zhao, Guangnan Peng, Miaojin Zhou, Wanxi Liu, Min Liu, Lingjie Ding, Desheng Liang, Xionghao Liu, Mujun Liu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
ALS
FTLD
UBQLN2
iPSCs
MNs
DNA damage
Online Access:https://www.mdpi.com/1422-0067/23/19/11333

Internet

https://www.mdpi.com/1422-0067/23/19/11333

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