Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo

Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo

Initiating translation of most eukaryotic mRNAs depends on recruitment of methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2) to the small (40S) ribosomal subunit, forming a 43S preinitiation complex (PIC) that attaches to the mRNA and...

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Bibliographic Details
Main Authors: Swati Gaikwad, Fardin Ghobakhlou, Hongen Zhang, Alan G Hinnebusch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
translation
eIF2A
eIF2
uORF
IRES
yeast
Online Access:https://elifesciences.org/articles/92916

Internet

https://elifesciences.org/articles/92916

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