Contrasting Local and Macroscopic Effects of Collagen Hydroxylation

Contrasting Local and Macroscopic Effects of Collagen Hydroxylation

Collagen is heavily hydroxylated. Experiments show that proline hydroxylation is important to triple helix (monomer) stability, fibril assembly, and interaction of fibrils with other molecules. Nevertheless, experiments also show that even without hydroxylation, type I collagen does assemble into it...

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Bibliographic Details
Main Authors: Sameer Varma, Joseph P. R. O. Orgel, Jay D. Schieber
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
molecular dynamics
polymers
fibril assembly
collagen
hydroxylation
Online Access:https://www.mdpi.com/1422-0067/22/16/9068

Internet

https://www.mdpi.com/1422-0067/22/16/9068

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