Comprehensive analysis of senescence-related genes and immune infiltration in intervertebral disc degeneration: a meta-data approach utilizing bulk and single-cell RNA sequencing data

Comprehensive analysis of senescence-related genes and immune infiltration in intervertebral disc degeneration: a meta-data approach utilizing bulk and single-cell RNA sequencing data

Objectives: This study aims to identify the key senescence genes and potential regulatory mechanisms that contribute to the etiology of intervertebral disc degeneration (IDD).Method: We analyzed GSE34095 and GSE70362 datasets, identifying key senescence-related differentially expressed genes (DEGs)...

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Bibliographic Details
Main Authors: Ya-Jun Deng, Xin-Gang Wang, Zhi Li, Bo Wang, Jie Li, Jun Ma, Xiong Xue, Xin Tian, Quan-Cheng Liu, Jia-Yuan Liu, Ying Zhang, Bin Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
intervertebral disc degeneration
senescence-related genes
immune infiltration
single-cell
risk score
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1296782/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1296782/full

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