Protocol for transcriptome-wide mapping of small-molecule RNA-binding sites in live cells

Summary: Small molecules targeting RNA can be valuable chemical probes and potential therapeutics. The interactions between small molecules, particularly fragments, and RNA, however, can be difficult to detect due to their modest affinities and short residence times. Here, we present a protocol for...

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Bibliographic Details
Main Authors: Yuquan Tong, Patrick R.A. Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L. Childs-Disney, Matthew D. Disney
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724004362