The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

The increasing number of poorly water-soluble drug candidates in pharmaceutical development is a major challenge. Enabling techniques such as amorphization of the crystalline drug can result in supersaturation with respect to the thermodynamically most stable form of the drug, thereby possibly incre...

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Bibliographic Details
Main Authors: Lasse I. Blaabjerg, Holger Grohganz, Eleanor Lindenberg, Korbinian Löbmann, Anette Müllertz, Thomas Rades
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Pharmaceutics
Subjects:
glass forming ability
amorphous
degree of supersaturation
precipitation inhibitor
pKa
Online Access:http://www.mdpi.com/1999-4923/10/4/164

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http://www.mdpi.com/1999-4923/10/4/164

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