Investigation of the Defective Growth Pattern and Multidrug Resistance in a Clinical Isolate of Candida glabrata Using Whole-Genome Sequencing and Computational Biology Applications

Investigation of the Defective Growth Pattern and Multidrug Resistance in a Clinical Isolate of Candida glabrata Using Whole-Genome Sequencing and Computational Biology Applications

ABSTRACT Candida glabrata is increasingly isolated from blood cultures, and multidrug-resistant isolates have important implications for therapy. This study describes a cholesterol-dependent clinical C. glabrata isolate (ML72254) that did not grow without blood (containing cholesterol) on routine my...

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Bibliographic Details
Main Authors: Osman Merdan, Ayşe Sena Şişman, Seçil Ak Aksoy, Samet Kızıl, Nazmiye Ülkü Tüzemen, Emel Yılmaz, Beyza Ener
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
amphotericin resistance
azole resistance
Candida glabrata
cholesterol dependent
ERG1
whole-genome sequencing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00776-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00776-22

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