Design, stereoselective synthesis, and antitumoral activity of combretastatin A-4 analogs

Design, stereoselective synthesis, and antitumoral activity of combretastatin A-4 analogs

Combretastatin A-4 (CA-4) is a microtubule targeting agent, and it has a great advantage when compared to other compounds with a similar mechanism of action, such as vinca alkaloids, colchicine, podophillotoxin, and paclitaxel: its simpler structure. In this work, the stereoselective synthesis and a...

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Bibliographic Details
Main Authors: Wilson P. da Silva, Robrigo R.A. Caiana, Maria E.S.B. Barros, Juliano C.R. Freitas, Paulo B.N. da Silva, Gardenia G.C. Militão, Roberta A. Oliveira, Paulo H. Menezes
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Combretastatin A-4
Antitumoral
Potassium organotrifluoroborates
Vinyl tellurides
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624002352

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http://www.sciencedirect.com/science/article/pii/S2211715624002352

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