CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection

CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection

ABSTRACT Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization and has binding sites in the HSV-1 ge...

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Bibliographic Details
Main Authors: Jennifer S. Lee, Priya Raja, Dongli Pan, Jean M. Pesola, Donald M. Coen, David M. Knipe
Format: Article
Language:English
Published: American Society for Microbiology 2018-03-01
Series:mBio
Subjects:
chromatin
epigenetics
herpes simplex virus
latent infection
regulation of gene expression
Online Access:https://journals.asm.org/doi/10.1128/mBio.02372-17

Internet

https://journals.asm.org/doi/10.1128/mBio.02372-17

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