Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Abstract Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes biosynthesize unique lipid mediator signatures when exposed to pathogenic bacteria. E. coli a...

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Bibliographic Details
Main Authors: Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02538-5

Internet

https://doi.org/10.1038/s41467-017-02538-5

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