Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

Multiple studies have indicated that in addition to direct oncolysis, virotherapy promotes an antitumor cytotoxic T cell response important for efficacy. To study this phenomenon further, we tested three syngeneic murine sarcoma models that displayed varied degrees of permissiveness to oncolytic her...

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Bibliographic Details
Main Authors: Jennifer L Leddon, Chun-Yu Chen, Mark A Currier, Pin-Yi Wang, Francesca A Jung, Nicholas L Denton, Kevin M Cripe, Kellie B Haworth, Michael A Arnold, Amy C Gross, Timothy D Eubank, William F Goins, Joseph C Glorioso, Justus B Cohen, Paola Grandi, David A Hildeman, Timothy P Cripe
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300043

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http://www.sciencedirect.com/science/article/pii/S2372770516300043

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