LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation.

LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation.

Pseudomonas aeruginosa causes chronic airway infections, a major determinant of lung inflammation and damage in cystic fibrosis (CF). Loss-of-function lasR mutants commonly arise during chronic CF infections, are associated with accelerated lung function decline in CF patients and induce exaggerated...

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Bibliographic Details
Main Authors: Lisa C Hennemann, Shantelle L LaFayette, Julien K Malet, Perrine Bortolotti, Tianxiao Yang, Geoffrey A McKay, Daniel Houle, Danuta Radzioch, Simon Rousseau, Dao Nguyen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009375

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https://doi.org/10.1371/journal.ppat.1009375

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