FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system

FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system

OBJECTIVE: Available chemotherapy presents poor control over the development of metastatic melanoma. FTY720 is a compound already approved by the Food and Drug Administration for the treatment of patients with multiple sclerosis. It has also been observed that FTY720 inhibits tumor growth in vivo (e...

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Bibliographic Details
Main Authors: Felipe V. Pereira, Denise C. Arruda, Carlos R. Figueiredo, Mariana H. Massaoka, Alisson L. Matsuo, Valquiria Bueno, Elaine G. Rodrigues
Format: Article
Language:English
Published: Elsevier España 2013-07-01
Series:Clinics
Subjects:
FTY720
Murine Melanoma B16F10
Apoptosis
Metastasis
Reactive Oxygen Species
β-Catenin
Immunomodulation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000701018&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000701018&lng=en&tlng=en

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