FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system

FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system

OBJECTIVE: Available chemotherapy presents poor control over the development of metastatic melanoma. FTY720 is a compound already approved by the Food and Drug Administration for the treatment of patients with multiple sclerosis. It has also been observed that FTY720 inhibits tumor growth in vivo (e...

Full description

Bibliographic Details
Main Authors:	Felipe V. Pereira, Denise C. Arruda, Carlos R. Figueiredo, Mariana H. Massaoka, Alisson L. Matsuo, Valquiria Bueno, Elaine G. Rodrigues
Format:	Article
Language:	English
Published:	Elsevier España 2013-07-01
Series:	Clinics
Subjects:	FTY720 Murine Melanoma B16F10 Apoptosis Metastasis Reactive Oxygen Species β-Catenin Immunomodulation
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000701018&lng=en&tlng=en

Similar Items

FTY720 in immuno-regenerative and wound healing technologies for muscle, epithelial and bone regeneration
by: Monica Behara, et al.
Published: (2023-05-01)

Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients
by: S.I. Park, et al.
Published: (2005-05-01)

The protective role of FTY720 in promoting survival of allograft fat in mice
by: Yi Yi, et al.
Published: (2022-09-01)

The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection
by: Alessandra Gonçalves Commodaro, et al.
Published: (2012-07-01)

Differential effects of FTY720 on the B cell compartment in a mouse model of multiple sclerosis
by: Kathrin Bail, et al.
Published: (2017-07-01)

Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis
by: Shaoheng He, et al.
Published: (2010-09-01)

Acute Anterior Uveitis in a Patient Taking Fingolimod (FTY720) for Multiple Sclerosis
by: Heather Gwen Mack, et al.
Published: (2016-12-01)

Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells
by: Yi Zhao, et al.
Published: (2018-07-01)

A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis
by: Kanako Hagihara, et al.
Published: (2017-11-01)

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
by: Laurent Kremer, et al.
Published: (2019-03-01)

Anti-tumor drug FTY720 regulates p53-dependent transcription
by: YAO Han, XU Wen-bin, WANG Dong-lai
Published: (2021-03-01)

Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation
by: Jitendra Shrestha, et al.
Published: (2018-10-01)

FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
by: Thomas V. Rousselle, et al.
Published: (2020-06-01)

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
by: Kyoung-jin Min, et al.
Published: (2020-11-01)

The Effects of the S1P Receptor Agonist Fingolimod (FTY720) on Central and Peripheral Myelin in Twitcher Mice
by: Sibylle Béchet, et al.
Published: (2024-03-01)

Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
by: Raffaela Cipriani, et al.
Published: (2017-07-01)

Cardioprotective Effects of Sphingosine-1-Phosphate Receptor Immunomodulator FTY720 in a Clinically Relevant Model of Cardioplegic Arrest and Cardiopulmonary Bypass
by: Naseer Ahmed, et al.
Published: (2019-07-01)

Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy
by: Wu JY, et al.
Published: (2018-03-01)

The emerging role of FTY720 as a sphingosine 1‐phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms
by: Maryam Naseh, et al.
Published: (2021-06-01)

Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade
by: Janet L. Martin, et al.
Published: (2017-08-01)

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4
by: Simone M. Crivelli, et al.
Published: (2022-08-01)

Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720
by: Alessandra Roggeri, et al.
Published: (2023-09-01)

FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes
by: Zhu C, et al.
Published: (2021-05-01)

FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells
by: Juan Pablo Muñoz, et al.
Published: (2023-04-01)

FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages
by: Koki Tachibana, et al.
Published: (2022-11-01)

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model
by: Georgia-Ioanna Kartalou, et al.
Published: (2020-11-01)

Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice
by: Takumi Tsuji, et al.
Published: (2016-04-01)

FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation
by: Naoya Hirata, et al.
Published: (2021-07-01)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
by: Jaeyoon Ryu, et al.
Published: (2020-06-01)

Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model
by: Naseer Ahmed, et al.
Published: (2020-09-01)

Effect of immunomodulator, fingolimod, on ischemia reperfusion testicular injury in rats: Targeting the role of sphingolipid rheostat (fingolimod on I/R induced testicular injury)
by: Marwa N. Emam, et al.
Published: (2017-06-01)

FTY720 in hematopoietic cell transplantation FTY720 no transplante de células hematopoéticas
by: Valquiria Bueno
Published: (2008-01-01)

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
by: Henryk Jęśko, et al.
Published: (2021-07-01)

Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma
by: Yunze Xu, et al.
Published: (2018-12-01)

Protein phosphatase 2A regulates xanthine oxidase-derived ROS production in macrophages and influx of inflammatory monocytes in a murine gout model
by: Sandy Elsayed, et al.
Published: (2022-11-01)

Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells
by: Ahmet Eken, et al.
Published: (2019-02-01)

Actions of FTY720 (Fingolimod), a Sphingosine-1-Phosphate Receptor Modulator, on Delayed-Rectifier K<sup>+</sup> Current and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Jurkat T-Lymphocytes
by: Wei-Ting Chang, et al.
Published: (2020-10-01)

Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner
by: Abhisarika Patnaik, et al.
Published: (2020-04-01)

Vesicle Fusion as a Target Process for the Action of Sphingosine and Its Derived Drugs
by: José Villanueva, et al.
Published: (2022-01-01)

Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod
by: Yasuyuki Kihara, et al.
Published: (2022-06-01)