Turnover of Variant Surface Glycoprotein in <named-content content-type="genus-species">Trypanosoma brucei</named-content> Is a Bimodal Process

Turnover of Variant Surface Glycoprotein in <named-content content-type="genus-species">Trypanosoma brucei</named-content> Is a Bimodal Process

ABSTRACT African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (GPI-PLC). However, GPI-PLC is topolo...

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Bibliographic Details
Main Authors: Paige Garrison, Umaer Khan, Michael Cipriano, Peter J. Bush, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Terry K. Smith, Stephen L. Hajduk, James D. Bangs
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
trypanosome
variant surface glycoprotein
glycosylphosphatidylinositol
glycosylphosphatidylinositol-specific phospholipase C
extracellular vesicles
Online Access:https://journals.asm.org/doi/10.1128/mBio.01725-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01725-21

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