Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling

Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling

Proliferation of smooth muscle cells, oxidative stress, and pulmonary vasoconstriction resulting from intermittent hypoxia (IH) facilitate pulmonary hypertension (PH) in patients with obstructive sleep apnea. The role of Phosphodiesterase 4 B (PDE4B) in PH has not yet been established. Herein, we in...

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Bibliographic Details
Main Authors: Zhou Pan, Xiaofeng Wu, Xinyue Zhang, Ke Hu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic intermittent hypoxia
Pulmonary hypertension
PDE4B
cAMP
ATF4
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014846

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http://www.sciencedirect.com/science/article/pii/S0753332222014846

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