From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis

From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis

Psoriatic arthritis (PsA) is a chronic inflammatory immune-mediated disease with a burdensome impact on quality of life and substantial healthcare costs. To date, pharmacological interventions with different mechanisms of action, including conventional synthetic (cs), biological (b), and targeted sy...

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Bibliographic Details
Main Authors: Ettore Silvagni, Sonia Missiroli, Mariasole Perrone, Simone Patergnani, Caterina Boncompagni, Alessandra Bortoluzzi, Marcello Govoni, Carlotta Giorgi, Stefano Alivernini, Paolo Pinton, Carlo Alberto Scirè
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
psoriatic arthritis
TNF-alfa
IL-23/IL-17 axis
JAK/STAT pathway
synovial histopathology
synovial biopsy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.672515/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.672515/full

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