From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis

From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis

Psoriatic arthritis (PsA) is a chronic inflammatory immune-mediated disease with a burdensome impact on quality of life and substantial healthcare costs. To date, pharmacological interventions with different mechanisms of action, including conventional synthetic (cs), biological (b), and targeted sy...

Full description

Bibliographic Details
Main Authors: Ettore Silvagni, Sonia Missiroli, Mariasole Perrone, Simone Patergnani, Caterina Boncompagni, Alessandra Bortoluzzi, Marcello Govoni, Carlotta Giorgi, Stefano Alivernini, Paolo Pinton, Carlo Alberto Scirè
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
psoriatic arthritis
TNF-alfa
IL-23/IL-17 axis
JAK/STAT pathway
synovial histopathology
synovial biopsy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.672515/full

Similar Items

Similar Items