High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

Summary: Type VI CRISPR-Cas systems contain programmable single-effector RNA-guided RNases, including Cas13b, one of the four known family members. Cas13b, which has been used for both RNA editing and nucleic acid detection, is unique among type VI CRISPR effectors in its linear domain architecture...

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Bibliographic Details
Main Authors: Ian M. Slaymaker, Pablo Mesa, Max J. Kellner, Soumya Kannan, Edward Brignole, Jeremy Koob, Patricia R. Feliciano, Stefano Stella, Omar O. Abudayyeh, Jonathan S. Gootenberg, Jonathan Strecker, Guillermo Montoya, Feng Zhang
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719302803

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http://www.sciencedirect.com/science/article/pii/S2211124719302803

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