Amplification of HER2 is a marker for global genomic instability

<p>Abstract</p> <p>Background</p> <p>Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given...

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Bibliographic Details
Main Authors: Love Brad, Deyarmin Brenda, Patney Heather L, Ellsworth Darrell L, Ellsworth Rachel E, Hooke Jeffrey A, Shriver Craig D
Format: Article
Language:English
Published: BMC 2008-10-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/297