Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice

Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice

Activation of Kupffer cells (KCs) by gut-derived lipopolysaccharide (LPS) instigates nuclear factor-κB (NF-κB)-mediated inflammatory responses in alcohol-associated liver diseases (ALD). Here, we utilized a novel optogenetically engineered exosome technology called ‘exosomes for protein loading via...

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Bibliographic Details
Main Authors: Hee-Hoon Kim, Young-Ri Shim, Sung Eun Choi, Tolulope Esther Falana, Jae-Kwang Yoo, So-Hee Ahn, Minhye Park, Hyangmi Seo, Chulhee Choi, Won-Il Jeong
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
alcohol-associated liver injury
exosome
nuclear factor-κB
inflammation
Kupffer cell
Online Access:https://www.mdpi.com/1999-4923/15/2/636

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https://www.mdpi.com/1999-4923/15/2/636

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